Insights into the autistic disorder and potential therapeutic approaches

Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches.

PURPOSE OF REVIEW Animal models have been extremely valuable in contributing to a better understanding of the pathogenesis of systemic sclerosis. Discussed here are recent studies that have examined the molecular pathways and potential therapeutic approaches for systemic sclerosis using animal models. RECENT FINDINGS Reported evidence further indicates that the immune system plays a role in m...

Recent insights into development, metabolic function and therapeutic potential

Multiple Myeloma: New Insights and Therapeutic Approaches.

This review discusses the evolution of novel diagnostic and treatment strategies for multiple myeloma based upon increased understanding of basic disease pathogenesis. Although myeloma has remained an incurable illness to date, these new developments will derive treatments to improve outcome and achieve eventual cure. In Section I, Dr. Kyle reviews the results of current therapy for multiple my...

Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches

In recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis still remains unclear. Aiming to better understand MRONJ physiopathology, the first objective of...

Sensory Integration and Autistic Spectrum Disorder

The theory and practice of sensory integration were developed in the late 1960s by an occupational therapist and psychologist, Dr. A. Jean Ayres [1]. Also, known as sensory processing, it is “the neurological process that organizes sensation from one’s own body and from the environment and makes it possible to use the body effectively within the environment” [1].   

Silymarin: Insights into Properties and Therapeutic Indications

Silymarin is the active ingredient of milk thistle. Several studies proved that silymarin has antioxidant, anti-inflammatory and anti-cancer properties. Silymarin is widely used for treatment of hepatic and biliary disorders, renal toxicity and is recently used as adjuvant agent for treatment of cancer.